I'm a big fan of the boinc project.  I like that I can help with research projects of all kinds.
Web site:  http://boinc.berkeley.edu/
I'm currently using the Ubuntu client and it's running nicely.  I run it in a virtual machine to keep my data separate and so I can completely turn it off when I need too.
  After issues with my machine I had to transfer the data.  The two areas I had to transfer to keep all my settings and the units I was working was:
         settings: /etc/boinc-client
         project data:  /var/lib/boinc-client   
  I used scp to copy the data between the two systems.  I stopped the client and copied over the data.  I tend to su to root to work.  Some people like to use sudo on each command but after years of working on unix machines I just go to root.  Not saying this is right it's just what I do. 
  sudo su -   
  service boinc-client stop
  cd /etc
  mv boinc-client boinc-client-old
  scp -rp  <old machine>:/etc/boinc-client  .
  cd  /var/lib
  mv boinc-client  boinc-client-old
  scp -rp  <old machine>:/var/lib/boinc-client .
  chmod -R boinc:boinc  /var/lib/boinc-client   /etc/boinc-client
Currently helping with the projects:
   FreeHal  https://www.freehal.net/
   Climate Prediction  climateprediction.net      (needs lots of disk space) 
   Docking   http://docking.cis.udel.edu
   Rosseta    http://boinc.bakerlab.org/rosetta
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